|
SOC Cohort
|
Rivaroxaban Cohort
|
SOC Cohort
|
Rivaroxaban Cohort
|
|
N=(1546)
|
N=(73)
|
N=(192)
|
N=(64)
|
|
N/Mean
|
%/STD
|
N/Mean
|
% SD
|
STD
|
N/Mean
|
%/SD
|
N/Mean
|
% SD
|
STD
|
|
Age
|
|
Mean, SD
|
59.9 |
11.1 |
59.8 |
11.7 |
0.3 |
57.8 |
11.2 |
60.2 |
11.9 |
20.4 |
|
Median
|
62 |
|
63 |
|
|
59.5 |
|
|
63 |
|
| 18-45 |
169 |
10.9% |
9 |
12.3% |
4.3 |
27 |
14.1% |
9 |
14.1% |
0.0 |
| 46-64 |
788 |
51.0% |
31 |
42.5% |
17.0 |
106 |
55.2% |
25 |
39.1% |
32.6 |
| 65+ |
589 |
38.1% |
33 |
45.2% |
14.4 |
59 |
30.7% |
30 |
46.9% |
33.4 |
|
Gender
|
| Male |
1439 |
93.1% |
71 |
97.3% |
19.6 |
185 |
96.4% |
62 |
96.9% |
2.9 |
|
Race
|
| White |
1000 |
64.7% |
42 |
57.5% |
14.6 |
129 |
67.2% |
40 |
62.5% |
9.8 |
| Black |
400 |
25.9% |
22 |
30.1% |
9.5 |
49 |
25.5% |
17 |
26.6% |
2.4 |
| Unknown |
101 |
6.5% |
7 |
9.6% |
11.2 |
8 |
4.2% |
5 |
7.8% |
15.3 |
| Other |
45 |
2.9% |
2 |
2.7% |
1.0 |
6 |
3.1% |
2 |
3.1% |
0.0 |
|
Body Mass Index
|
| Body Mass Index (in kg/m2) |
31.7 |
9.5 |
32.3 |
6.4 |
7.5 |
32.2 |
7.3 |
32.6 |
6.7 |
5.2 |
|
Baseline Comorbid Conditions
|
|
Charlson Comorbidity Index Score
|
1.0 |
1.4 |
0.5 |
0.9 |
35.1 |
0.4 |
0.8 |
0.5 |
0.9 |
12.2 |
| Myocardial Infarction |
72 |
4.7% |
3 |
4.1% |
2.7 |
3 |
1.6% |
2 |
3.1% |
10.3 |
| Congestive heart failure |
0 |
0.0% |
0 |
0.0% |
0.0 |
0 |
0.0% |
0 |
0.0% |
0.0 |
| Peripheral vascular disease |
84 |
5.4% |
3 |
4.1% |
6.2 |
9 |
4.7% |
3 |
4.7% |
0.0 |
| Dementia |
11 |
0.7% |
0 |
0.0% |
12.0 |
0 |
0.0% |
0 |
0.0% |
0.0 |
| Cerebrovascular disease |
133 |
8.6% |
3 |
4.1% |
18.4 |
4 |
2.1% |
3 |
4.7% |
14.3 |
| Chronic pulmonary disease |
108 |
7.0% |
6 |
8.2% |
4.6 |
17 |
8.9% |
5 |
7.8% |
3.8 |
| Rheumatologic disease or connective tissue disease |
23 |
1.5% |
0 |
0.0% |
17.4 |
0 |
0.0% |
0 |
0.0% |
0.0 |
| Peptic Ulcer disease |
26 |
1.7% |
1 |
1.4% |
2.5 |
2 |
1.0% |
1 |
1.6% |
4.6 |
| Mild liver disease |
15 |
1.0% |
0 |
0.0% |
14.0 |
0 |
0.0% |
0 |
0.0% |
0.0 |
| Hemiplegia or paraplegia |
0 |
0.0% |
0 |
0.0% |
0.0 |
0 |
0.0% |
0 |
0.0% |
0.0 |
| Moderate or severe renal disease |
270 |
17.5% |
8 |
11.0% |
12.6 |
8 |
4.2% |
6 |
9.4% |
14.3 |
| Diabetes |
414 |
26.8% |
12 |
16.4% |
25.2 |
30 |
15.6% |
11 |
17.2% |
4.2 |
| Any tumor |
12 |
0.8% |
0 |
0.0% |
8.8 |
2 |
1.0% |
0 |
0.0% |
10.2 |
| Moderate or severe liver disease |
12 |
0.8% |
0 |
0.0% |
7.2 |
0 |
0.0% |
0 |
0.0% |
0.0 |
| Metastatic solid tumor |
0 |
0.0% |
0 |
0.0% |
0.0 |
0 |
0.0% |
0 |
0.0% |
0.0 |
| Diabetes + complications |
182 |
11.8% |
4 |
5.5% |
15.5 |
10 |
5.2% |
4 |
6.3% |
3.1 |
| AIDS |
120 |
7.8% |
0 |
0.0% |
16.2 |
0 |
0.0% |
0 |
0.0% |
0.0 |
| Cardiac Dysrhythmia |
224 |
14.5% |
6 |
8.2% |
19.8 |
18 |
9.4% |
6 |
9.4% |
0.0 |
| LV dysfunction |
34 |
2.2% |
1 |
1.4% |
6.2 |
0 |
0.0% |
1 |
1.6% |
17.7 |
| Hospitalized DVT |
525 |
34.0% |
24 |
32.9% |
2.3 |
80 |
41.7% |
21 |
32.8% |
18.3 |
|
Baseline Diagnostic tests
|
| CTA |
809 |
52.3% |
43 |
58.9% |
13.2 |
113 |
58.9% |
37 |
57.8% |
2.1 |
| ECHO |
32 |
2.1% |
2 |
2.7% |
4.4 |
4 |
2.1% |
0 |
0.0% |
20.6 |
| VQ Scan |
37 |
2.4% |
0 |
0.0% |
22.1 |
0 |
0.0% |
0 |
0.0% |
0.0 |
| Venous Doppler Ultrasound |
314 |
20.3% |
12 |
16.4% |
10.0 |
43 |
22.4% |
9 |
14.1% |
21.6 |
|
Clinical Characteristics During Index Hospitalization
|
|
Index hospital Length of stay (days)
|
8.2 |
15.6 |
6.2 |
16.3 |
12.4 |
7.0 |
19.8 |
6.7 |
21.8 |
1.8 |
|
Hospital acquired complications (HACs) during index hospitalization, ANY
|
155 |
10.0% |
4 |
5.5% |
17.0 |
20 |
10.4% |
3 |
4.7% |
21.7 |
|
Catheter-associated Urinary Tract Infection
|
4 |
0.3% |
0 |
0.0% |
7.2 |
0 |
0.0% |
0 |
0.0% |
0.0 |
|
Methicillin-resistant Staphylococcus Aureus (MRSA)
|
6 |
0.4% |
0 |
0.0% |
8.8 |
0 |
0.0% |
0 |
0.0% |
0.0 |
|
Clostridium Difficile Infection
|
9 |
0.6% |
0 |
0.0% |
10.8 |
0 |
0.0% |
0 |
0.0% |
0.0 |
|
Hospital Acquired (Bacterial) Pneumonia
|
94 |
6.1% |
3 |
4.1% |
8.9 |
9 |
4.7% |
2 |
3.1% |
8.0 |
|
Foreign Object Retained After Surgery
|
1 |
0.1% |
0 |
0.0% |
3.6 |
0 |
0.0% |
0 |
0.0% |
0.0 |
|
Pressure Ulcer Stages III & IV
|
2 |
0.1% |
0 |
0.0% |
5.1 |
0 |
0.0% |
0 |
0.0% |
0.0 |
|
Trauma/Injury
|
45 |
2.9% |
1 |
1.4% |
10.6 |
10 |
5.2% |
1 |
1.6% |
20.2 |
|
Poor Glycemic Control
|
7 |
0.5% |
0 |
0.0% |
9.5 |
1 |
0.5% |
0 |
0.0% |
10.2 |
|
Vascular Catheter-associated Infection
|
1 |
0.1% |
0 |
0.0% |
3.6 |
0 |
0.0% |
0 |
0.0% |
0.0 |
|
Surgical Site Infection
|
2 |
0.1% |
0 |
0.0% |
5.1 |
0 |
0.0% |
0 |
0.0% |
0.0 |
| Bacterial Pneumonia |
154 |
10.0% |
3 |
4.1% |
23.0 |
14 |
7.3% |
2 |
3.1% |
18.8 |
|
Clinical marker testing during the index hospitalization
|
| # Patients with Troponin I |
558 |
36.1% |
20 |
27.4% |
18.7 |
52 |
27.1% |
17 |
26.6% |
1.2 |
| # Patients with Troponin T |
29 |
1.9% |
1 |
1.4% |
4.0 |
3 |
1.6% |
1 |
1.6% |
0.0 |
| # Patients with BNP |
391 |
25.3% |
28 |
38.4% |
28.2 |
69 |
35.9% |
22 |
34.4% |
3.3 |
| # of Patients with NT Pro BNP |
150 |
9.7% |
9 |
12.3% |
8.4 |
17 |
8.9% |
7 |
10.9% |
6.9 |