|
Resource use
|
|
|
|
|
Proportion of patients requiring hospitalization
|
|
|
|
| Neutropenia |
0.05 |
0.04 |
0.06 |
| Febrile neutropenia |
0.5 |
0.4 |
0.6 |
| Fatigue |
0.3 |
0.24 |
0.36 |
| Nausea |
0.45 |
0.36 |
0.54 |
| Vomiting |
0.65 |
0.52 |
0.78 |
| Anaemia |
0.38 |
0.3 |
0.46 |
| Thrombocytopenia |
0.13 |
0.1 |
0.16 |
| Hypokalemia |
0.75 |
0.6 |
0.9 |
| Bone Pain |
0.34 |
0.27 |
0.41 |
| Diarrhoea |
0.43 |
0.34 |
0.52 |
|
Management resource use
|
|
|
|
|
Stable disease
|
|
|
|
| Physician outpatient visit (per week) |
0.08 |
0.06 |
0.1 |
| Imaging CT scan – abdominal (per week) |
0.04 |
0.03 |
0.05 |
| Imaging bone scan (per week) |
0.06 |
0.05 |
0.07 |
| Complete blood count (per week) |
0.08 |
0.06 |
0.1 |
| Prostatic Specific Antigen (per week) |
0.08 |
0.06 |
0.1 |
|
Length of stay (days per year) ALP based
|
|
|
|
| Pre-SSE radium-223 |
5.05 |
3.84 |
6.42 |
| Pre-SSE BSC |
6.14 |
3.97 |
8.78 |
| Post-SSE radium-223 |
20.78 |
13.9 |
29.02 |
| Post-SSE BSC |
41.18 |
26.24 |
59.43 |
|
Care Center Use (days per year) ALP based
|
|
|
|
| Pre-SSE radium-223 |
0.43 |
0.16 |
0.82 |
| Pre-SSE BSC |
0.56 |
0.19 |
1.12 |
| Post-SSE radium-223 |
1.38 |
0.38 |
3.02 |
| Post-SSE BSC |
1.05 |
0.09 |
3.19 |
|
Physician visits (visits per year) ALP based
|
|
|
|
| Pre-SSE radium-223 |
6.04 |
5.23 |
6.91 |
| Pre-SSE BSC |
5.72 |
4.73 |
6.8 |
| Post-SSE radium-223 |
9.99 |
7.74 |
12.52 |
| Post-SSE BSC |
11.09 |
5.8 |
18.06 |
|
Progressed disease
|
|
|
|
| Physician outpatient visit (per week) |
0.25 |
0.2 |
0.3 |
| Imaging CT scan – abdominal (per week) |
0.08 |
0.06 |
0.1 |
| Imaging bone scan (per week) |
0.08 |
0.06 |
0.1 |
| Complete blood count (per week) |
0.08 |
0.06 |
0.1 |
| Prostatic Specific Antigen (per week) |
0.08 |
0.06 |
0.1 |
|
Length of stay (days per year) ALP based
|
|
|
|
| Pre-SSE radium-223 |
7.7 |
4.36 |
11.97 |
| Pre-SSE BSC |
12.94 |
7.51 |
19.83 |
| Post-SSE radium-223 |
34.67 |
19.12 |
54.77 |
| Post-SSE BSC |
30.19 |
16.85 |
47.36 |
|
Care Center Use (days per year) ALP based
|
|
|
|
| Pre-SSE radium-223 |
|
|
|
| Pre-SSE BSC |
0.02 |
0 |
0.07 |
| Post-SSE radium-223 |
0.68 |
0.02 |
2.41 |
| Post-SSE BSC |
3.47 |
0.75 |
8.23 |
|
Physician visits (visits per year) ALP based
|
|
|
|
| Pre-SSE radium-223 |
9.68 |
5.67 |
14.75 |
| Pre-SSE BSC |
8.42 |
4.92 |
12.84 |
| Post-SSE radium-223 |
13.97 |
5.58 |
26.14 |
| Post-SSE BSC |
9.84 |
6.46 |
13.92 |
|
Unit costs
|
|
|
|
| Radium-223 |
4532.5 |
|
|
| Hospitalization day cost |
443.61 |
354.89 |
532.33 |
| Day Care Center Cost per Day |
186.26 |
149.01 |
223.51 |
| Physician visits |
81.02 |
64.82 |
97.22 |
| End of life care |
4181.67 |
3345.34 |
5018 |
| External beam radiation |
2427.72 |
1942.75 |
2913.26 |
|
Outpatient costs for adverse events
|
|
|
|
| Neutropenia |
273.1 |
218.48 |
327.72 |
| Febrile neutropenia |
7168.1 |
5734.48 |
8601.72 |
| Fatigue |
0 |
0 |
0 |
| Nausea |
0.51 |
0.41 |
0.61 |
| Vomiting |
15.41 |
12.33 |
18.49 |
| Anaemia |
501.83 |
401.46 |
602.2 |
| Thrombocytopenia |
387.28 |
309.82 |
464.74 |
| Hypokalemia |
1.55 |
1.24 |
1.86 |
| Bone Pain |
453.6 |
362.88 |
544.32 |
| Diarrhoea |
12 |
9.6 |
14.4 |