Patient Characteristics - Population A Sickle Cell patients N=20,909
N/Mean %/SD
Age (years) 17.94 15.17
<2 1579 7.55%
2-5 3662 17.51%
6-11 3604 17.24%
12-17 3543 16.94%
18-30 4421 21.14%
31-45 2521 12.06%
46-64 1526 7.30%
65+ 53 0.25%
Sex
Male 9179 43.90%
Female 11730 56.10%
Race/Ethnicity
White 1448 6.93%
Black 13727 65.65%
Hispanic 2715 12.98%
Other 622 2.97%
Unknown 2397 11.46%
Geographic Region
Northeast 7671 36.69%
North Central 2705 12.94%
South 6715 32.12%
West 3818 18.26%
Charlson Comorbidity Index Score 0.42 0.96
0 15688 75.03%
1 3369 16.11%
2-3 1474 7.05%
4+ 378 1.81%
Patients with Baseline VOC 2680 12.82%
Individual Comorbid Conditions*
Pulmonary
Upper respiratory tract infections 2744 13.12%
Asthma 2347 11.22%
Acute Chest Syndrome 577 2.76%
Pulmonary embolism 111 0.53%
Pulmonary hypertension 95 0.45%
Oncologic
Neoplasms benign and malignant 926 4.43%
Cerebrovascular
Seizures 647 3.09%
Stroke 342 1.64%
Spleen
Splenic sequestration 112 0.54%
Hypersplenism 20 0.10%
Others
Infectious and parasitic diseases 3781 18.08%
Fever 3242 15.51%
Constipation 1085 5.19%
Iron overload 590 2.82%
Aseptic (Avascular) bone necrosis 445 2.13%
Baseline SCD Management
SCD Medication
Antibiotics 10252 49.03%
Acetaminophen 7455 35.65%
Folic Acid 6103 29.19%
NSAIDs 4780 22.86%
Opioids (Narcotics) 2943 14.08%
Hydroxyurea 1899 9.08%
Iron Chelating therapy 788 3.77%
Other SCD Management
Blood transfusions 2277 10.89%
Transcranial Doppler ultrasonography 1024 4.90%
Pneumococcal vaccine 1020 4.88%
Meningococcal vaccine 226 1.08%
Bone marrow transplants 17 0.08%
Baseline All-cause Health Care Resource Utilization for all patients (6 months)
Any inpatient stay 4993 23.88%
Any outpatient emergency room visit 9513 45.50%
Any outpatient office visit 15342 73.38%
Any outpatient hospital visit 13692 65.48%
Any ambulatory surgery center visit 346 1.65%
Any lab visit 5810 27.79%
Any outpatient other visit 7505 35.89%
Any pharmacy visit 17 205 82.29%