Comorbid Condition Combinations	Overall (n = 223 923)	Age (Years)			Gender
		<65 (n = 38 429)	≥65 (n = 185 494)	P Value	Female (n = 94 557)	Male (n = 129 366)	P Value
Dyads
HLD-HTN	78.72	65.46	81.47	<.0001	77.35	79.72	<.0001
HTN-PAI	68.67	61.95	70.06	<.0001	73.59	65.08	<.0001
HLD-PAI	66.18	59.88	67.48	<.0001	69.53	63.73	<.0001
DM-HTN	40.01	37.03	40.61	<.0001	39.27	40.53	<.0001
DM-HLD	38.56	35.46	39.20	<.0001	37.38	39.43	<.0001
HTN-OBE	35.66	37.61	35.25	<.0001	36.32	35.17	<.0001
HLD-OBE	34.40	35.61	34.14	<.0001	34.45	34.35	.6342
FSR-HTN	33.85	28.19	35.02	<.0001	38.79	30.24	<.0001
DM—PAI	33.76	33.01	33.91	.0006	34.89	32.93	<.0001
HTN-OST	32.46	20.25	34.99	<.0001	39.20	27.53	<.0001
Triads
HLD-HTN-PAI	61.12	51.68	63.08	<.0001	64.27	58.82	<.0001
HLD-HTN-DM	37.10	33.19	37.91	<.0001	36.11	37.82	<.0001
HLD-HTN-OBE	32.71	32.55	32.75	.4433	32.78	32.67	.5912
HYP-PAI-DM	32.41	30.68	32.77	<.0001	33.58	31.55	<.0001
DM-HLD-PAI	31.19	29.27	31.59	<.0001	31.98	30.62	<.0001
HLD-HTN-FSR	30.26	23.75	31.61	<.0001	34.08	27.46	<.0001
HTN-OBE-PAI	29.36	31.56	28.91	<.0001	31.55	27.76	<.0001
HTN-PAI-FSR	29.29	24.93	30.20	<.0001	34.72	25.33	<.0001
HLD-HTN-OST	29.16	17.33	31.62	<.0001	34.62	25.18	<.0001
HTN-PAI-OST	28.76	18.67	30.85	<.0001	35.58	23.77	<.0001
Quartets
HLD-HTN-PAI-DM	30.16	27.63	30.68	<.0001	31.00	29.54	<.0001
HLD-HTN-PAI-OBE	26.94	27.34	26.86	.0525	28.49	25.81	<.0001
HLD-HTN-PAI-FSR	26.25	21.06	27.33	<.0001	30.60	23.08	<.0001
HLD-HTN-PAI-OST	25.87	15.96	27.93	<.0001	31.48	21.78	<.0001
HLD-HTN-DIA-OBE	18.79	19.69	18.62	<.0001	19.00	18.65	.0400
HLD-HTN-PAI-CHF	17.83	12.74	18.88	<.0001	18.60	17.27	<.0001
HLD-HTN-PAI-CKD	17.21	9.70	18.76	<.0001	17.72	16.84	<.0001
HTN-PAI-DM-OBE	16.93	18.67	16.57	<.0001	18.03	16.13	<.0001
DM-HLD-PAI-OBE	16.36	17.77	16.07	<.0001	17.26	15.71	<.0001
HLD-HTN-PAI-COP	16.29	12.33	17.11	<.0001	17.88	15.13	<.0001
Quintets
HLD-HTN-PAI-DM-OBE	16.01	17.13	15.78	<.0001	16.89	15.36	<.0001
HLD-HTN-PAI-DM-FSR	13.19	11.64	13.52	<.0001	14.81	12.02	<.0001
HLD-HTN-PAI-OBE-OST	12.98	10.09	13.59	<.0001	15.76	10.96	<.0001
HLD-HTN-PAI-DM-OST	12.76	9.11	13.52	<.0001	15.22	10.97	<.0001
HLD-HTN-PAI-FSR-OST	12.55	7.86	15.53	<.0001	16.44	9.72	<.0001
HLD-HTN-PAI-OBE-FSR	11.99	12.10	11.97	.4729	13.87	10.61	<.0001
HLD-HTN-PAI-DM-CKD	10.72	7.22	11.45	<.0001	10.82	10.65	.2131
HLD-HTN-PAI-DM-CHF	10.28	8.41	10.66	<.0001	10.40	10.19	.1089
HLD-HTN-PAI-FSR-CHF	9.10	6.19	9.71	<.0001	10.29	8.23	<.0001
HLD-HTN-PAI-OBE-CHF	9.04	7.92	9.27	<.0001	9.52	8.69	<.0001
Sextets
HLD-HTN-PAI-DM-OBE-OST	7.61	6.55	7.83	<.0001	9.24	6.43	<.0001
HLD-HTN-PAI-DM-OBE-FSR	7.23	7.72	7.13	<.0001	8.24	6.49	<.0001
HLD-HTN-PAI-DM-OST-FSR	6.30	4.59	6.65	<.0001	7.99	5.06	<.0001
HLD-HTN-PAI-DM-OBE-CHF	6.04	5.80	6.09	.0305	6.29	5.86	<.0001
HLD-HTN-PAI-DM-OBE-CKD	5.98	4.85	6.21	<.0001	6.29	5.74	<.0001
HLD-HTN-PAI-DM-FSR-CHF	5.29	4.18	5.52	<.0001	5.76	4.94	<.0001
HLD-HTN-PAI-DM-FSR-CKD	5.21	3.48	5.57	<.0001	5.63	4.91	<.0001
HLD-HTN-PAI-DM-CKD-CHF	5.20	3.65	5.53	<.0001	5.28	5.15	.1981
HLD-HTN-PAI-DM-OST-CKD	4.83	2.54	5.30	<.0001	5.63	4.24	<.0001
HLD-HTN-PAI-DM-OBE-COP	4.80	5.02	4.75	.0230	5.17	4.52	<.0001