Parameter	Hemophilia A			Hemophilia B
	Moderate (n=66)	Severe (n=115)	Moderate and Severe (n=181)	Moderate (n=28)	Severe (n=79)	Moderate and Severe (n=107)
Bleeding outcomes
ABR, mean (SD)	2.77 (3.57)	4.36 (9.38)	3.78 (7.80)	3.64 (4.27)	4.57 (6.44)	4.33 (5.94)
Cause of bleeding (proportion), % (SD)
Trauma-related bleeding events	59.14 (29.43)	58.70 (29.52)	58.86 (29.41)	67.86 (29.48)	60.03 (27.93)	62.11 (28.42)
Spontaneous bleeding events	40.86 (29.43)	41.30 (29.52)	41.14 (29.41)	32.14 (29.48)	39.97 (27.93)	37.89 (28.42)
Target joints, n (%)a	23 (34.85)	61 (53.04)	84 (46.41)	9 (32.14)	20 (25.32)	29 (27.10)
Distribution of target joints, n (%)
Ankle	3 (4.55)	12 (10.43)	15 (8.29)	2 (7.14)	4 (5.06)	6 (5.61)
Elbow	2 (3.03)	12 (10.43)	14 (7.73)	3 (10.71)	5 (6.33)	8 (7.48)
Hip	6 (9.09)	13 (11.30)	19 (10.50)	1 (3.57)	7 (8.86)	8 (7.48)
Knee	14 (21.21)	44 (38.26)	58 (32.04)	3 (10.71)	9 (11.39)	12 (11.21)
Neck	1 (1.52)	1 (0.87)	2 (1.10)	2 (7.14)	1 (1.27)	3 (2.80)
Shoulder	4 (6.06)	7 (6.09)	11 (6.08)	3 (10.71)	2 (2.53)	5 (4.67)
Spine	1 (1.52)	1 (0.87)	2 (1.10)	NR	2 (2.53)	2 (1.87)
Wrist	1 (1.52)	6 (5.22)	7 (3.87)	1 (3.57)	NR	1 (0.93)
Problem joints, n (%) b	31 (46.97)	55 (47.83)	86 (47.51)	8 (28.57)	38 (48.10)	46 (42.99)
Distribution of problem joints, n (%)
Ankle	12 (18.18)	16 (13.91)	28 (15.47)	1 (3.57)	12 (15.19)	13 (12.15)
Elbow	2 (3.03)	9 (7.83)	11 (6.08)	0 (0.00)	5 (6.33)	5 (4.67)
Hip	9 (13.64)	10 (8.70)	19 (10.50)	NR	7 (8.86)	7 (6.54)
Knee	17 (25.76)	31 (26.96)	48 (26.52)	3 (10.71)	22 (27.85)	25 (23.36)
Neck	NR	NR	NR	NR	NR	NR
Shoulder	2 (3.03)	9 (7.83)	11 (6.08)	2 (7.14)	4 (5.06)	6 (5.61)
Spine	4 (6.06)	3 (2.61)	7 (3.87)	1 (3.57)	NR	1 (0.93)
Wrist	4 (6.06)	6 (5.22)	10 (5.52)	1 (3.57)	4 (5.06)	5 (4.67)
Joint procedures (in prior 12 months), n (%)	10 (15.15)	29 (25.22)	39 (21.55)	1 (3.57)	5 (6.33)	6 (5.61)
Distribution of joint procedures, n (%)
Ankle	2 (3.03)	NR	2 (1.10)	NR	1 (1.27)	1 (0.93)
Elbow	NR	1 (0.87)	1 (0.55)	NR	1 (1.27)	1 (0.93)
Hip	1 (1.52)	5 (4.35)	6 (3.31)	NR	1 (1.27)	1 (0.93)
Knee	6 (9.09)	26 (22.61)	32 (17.68)	NR	1 (1.27)	1 (0.93)
Neck	NR	NR	NR	NR	1 (1.27)	1 (0.93)
Shoulder	2 (3.03)	3 (2.61)	5 (2.76)	1 (3.57)	NR	1 (0.93)
Spine	NR	NR	NR	NR	NR	NR
Wrist	1 (1.52)	NR	1 (0.55)	NR	NR	NR
Surgical intervention type, n (%)
Arthrocentesis	9 (13.64)	24 (20.87)	33 (18.23)	NR	6 (7.59)	6 (5.61)
Arthroscopy	6 (9.09)	9 (7.83)	15 (8.29)	NR	3 (3.80)	3 (2.80)
Arthrodesis	2 (3.03)	5 (4.35)	7 (3.87)	NR	NR	NR
Synovectomy	1 (1.52)	3 (2.61)	4 (2.21)	1 (3.57)	2 (2.53)	3 (2.80)
Arthroplasty	2 (3.03)	2 (1.74)	4 (2.21)	NR	1 (1.27)	1 (0.93)
No. of joint procedures, mean (SD; n)
Total sample	0.58 (2.17; 66)	0.63 (1.76; 115)	0.61 (1.91; 181)	0.04 (0.19; 28)	0.15 (0.46; 79)	0.12 (0.41; 107)
Patients with ≥1 procedure	3.80 (4.52; 10)	2.48 (2.80; 29)	2.82 (3.31; 39)	1.00 (NA; 1)	1.33 (0.48; 9)	1.30 (0.48; 10)
No. of hospital admissions, mean (SD; n)
Related to bleeding events c
Occurrences in the total sample	0.61 (0.70; 66)	0.72 (1.03; 115)	0.68 (0.92; 181)	0.50 (0.81; 28)	1.11 (0.81; 79)	0.89 (0.86; 107)
Occurrences in patients with ≥1 bleed-related hospitalization	1.21 (0.48; 33)	1.73 (0.89; 48)	1.52 (0.79; 81)	1.44 (0.73; 9)	1.36 (0.68; 36)	1.38 (0.68; 45)
Related to joint procedures d
Occurrences in the total sample	0.36 (1.35; 66)	0.39 (1.01; 115)	0.38 (1.14; 181)	0.04 (0.19; 28)	0.14 (0.42; 79)	0.11 (0.37; 107)
Occurrences in patients with ≥1 procedure-related ward stays	2.67 (2.83; 9)	1.88 (1.45; 24)	2.09 (1.91; 33)	1.00 (NA; 1)	1.22 (0.44; 9)	1.20 (0.42; 10)
Chronic pain level related to hemophilia, n (%)
No pain	18 (27.27)	33 (28.70)	51 (28.18)	10 (35.71)	8 (10.13)	18 (16.82)
Mild pain	24 (36.36)	34 (29.57)	58 (32.04)	11 (39.29)	40 (50.63)	51 (47.66)
Moderate pain	22 (33.33)	38 (33.04)	60 (33.15)	7 (25.00)	26 (32.91)	33 (30.84)
Severe pain	2 (3.03)	10 (8.70)	12 (6.63)	NR	5 (6.33)	5 (4.67)