Parameter Units Base Case Uncertainty Distribution Source
Starting age Years 66.90 42.2-91.6 Normal Beyer-Westendorf et al[@265105]
Gender split Proportion female 0.59 0.53-0.65 Beta Beyer-Westendorf et al[@265105]
Hip arthroplasty (THA) Proportion 0.50 0.45-0.55 Beta Assumption
Knee arthroplasty Proportion 1-THA Assumption
High-risk patients Proportion 0.10 0.09-0.11 Beta Assumption
SSI incidence Proportion 0.028 0.025-0.031 Beta Hardtstock et al,[@265097] adjusted for SSI as reported in Anderson et al[@265106]
SSI incidence after surgery Days 13.95 Hardtstock et al[@265097]
Surgical time with intraoperative warming Minutes 116.09 104.48-127.7 Gamma Frisch et al[@265096] adjusted given meta-analysis by Balki et al[@265107]
Hypothermia (active warming)
THA Proportion 0.439 0.395-0.483 Beta Frisch et al[@265096]
TKA Proportion 0.326 0.293-0.359 Beta Frisch et al[@265096]
Hypothermia (passive warming) Proportion 0.964 0.868-1.000 Beta Sari et al17
Surgical time without intraoperative warming Minutes 114.15 102.74-125.57 Gamma Frisch et al[@265096]
Additional time in PACU managing hypothermia Minutes 3.90 3.51-4.29 Gamma Eksert & Sir[@265108]
Time spent in PACU Minutes 35.46 31.91-39.00 Gamma Eksert & Sir[@265108]
High-risk patient risk factor: SSI (both superficial and deep) RR 1.65 1.33-2.00 Log-normal
Hypothermia risk factor
Superficial SSI RR 1.21 0.95-1.54 Log-normal Geurts et al[@265103]
Deep SSI OR 3.30 1.19-9.14 Log-normal Frisch et al[@265094]
Superficial SSI risk factor: Ioban™ incise drapes RR 0.31 0.28-0.35 Log-normal Bejko et al[@265101]
Deep SSI risk factor: Ioban™ incise drapes RR 0.29 0.28-0.35 Log-normal Bejko et al[@265101]
SSI risk factor: Prevena™ RR 0.16 0.19-1.64 Log-normal Singh et al[@265104]
Impact on hypothermia, Bair Hugger™ RR 0.71 0.64-0.78 Log-normal Shaw et al[@265102]
Total cost, 3M™ Ioban™ incise drapes Euros 7.50 6.75-8.25 Gamma Assumed 1.5x SoC
Total cost, SoC clear incise drape Euros 5.00 4.5-5.50 Gamma Assumption
Total cost, 3M™ Bair Hugger™ pre- and intraoperative warming gown Euros 13.89 12.50-15.28 Gamma Macario & Clancy[@265109]
Total cost, SoC pre- and intraoperative warming gown Euros 9.94 8.95-10.93 Gamma Macario & Clancy[@265109]
Total cost, 3M™ Prevena™ Incision Management System Euros 345.00 310.50-379.50 Gamma 3M data on file, rounded to the nearest €5
Total cost, SoC antimicrobial dressing Euros 5.00 4.50-5.50 Gamma Assumption
GW cost (no infection, per day) Euros 296.32 266.69-325.95 Gamma Haenle et al[@265082]
GW cost (infection, per day) Euros 318.99 287.09-350.89 Gamma Haenle et al[@265082]
OR cost (per day) Euros 1343.26 1208.93-1477.58 Gamma Assumed similar to ICU cost
ICU cost (per day) Euros 1343.26 1208.93-1477.58 Gamma Haenle et al[@265082]
PACU cost (per day) Euros 296.32 266.69-325.95 Gamma Assumed similar to GW
Outpatient physician visit cost (per day) Euros 168.48 151.63-185.32 Gamma Hardtstock et al[@265097]