Total US COPD Population ETHOS-Eligible
Population
Expanded ETHOS-
Eligible Population
Current Higher SITT
Adoption: ETHOS-
Eligible Population
Higher SITT
Adoption: Expanded
ETHOS-Eligible
Population
Current Higher
SITT

Adoption
Current Higher
SITT

Adoption
Total years of life (millions) 254.7 255.5 257.2 20.7 21.5 60.8 63.3
Severe exacerbations
(millions)
38.7 38.1 36.7 5.4 4.8 17.4 15.4
Moderate exacerbations
(millions)
202.2 199.6 194.4 21.4 18.8 65 57.1
Deaths (millions) 10.7 10.5 10.2 0.8 0.7 3.3 2.8
≥1 severe exacerbation (%) 13.5 13.3 12.9 22.5 19.5 24.3 21.1
≥1 moderate exacerbation
(%)
53.5 53.0 52.1 63.9 57.9 65.0 59.0
All-⁠cause mortality rate (%) 4.2 4.1 3.9 4.0 3.0 5.4 4.3
All-cause mortality rate on
triple therapy (%)
4.6 4.0 4.3 3.1 3.0 4.7 4.3