Author (Year)	Country	Other QOL Tests
Fragoso et al (2013)[@147106]	Brazil	12% of patients with MS <18 y used physiotherapy and hydrotherapy
Grover et al (2016)[@147096]	Canada	Median (IQR) (patients with MS 12-18 y vs healthy controls)     Physical activity self-efficacy: 1.4 (0.6) vs 1.6 (0.4)     Perceived disability: 4.0 (7.0) vs 2.0 (3.0) Min/day of total physical activity     Median (IQR) measured via accelerometer: 106.3 (60.1) vs 105.0 (68.5)     Mean (SD) self-reported measured via GLTEQ: 43.4 (32.6) vs 67.5 (33.2)
Kinnett-Hopkins et al (2016)[@147099]	Canada	Median (IQR) min/day of total physical activity measured via accelerometer (patients with MS 8-18 y vs healthy controls): 106.33 (60.11), 109.00 (78.55) Median (IQR) self-reported exercise (min/wk) measured via GLTEQ: 36.00 (41.00) vs 65.00 (36.50)
Stephens et al (2019)[@147100]	Canada	Mean (SD) physical activity level using GLTEQ among patients with MS <18 y     Light activity: 9.1 (8.3)     Moderate activity: 15.99 (12.2)     Vigorous activity: 20.1 (21.5)     Health Contribution Score/moderate-to-vigorous physical activity: 35.5 (30.1)
Blaschek et al (2013)[@147098]	Germany	Mean (SD) sec on timed 25-Foot Walk Test among patients with MS 12-17 y: 3.73 (1.3)
Toussaint-Duyster et al (2018)[@147077]	Netherlands	Movement Assessment Battery for Children among patients with MS 4-17 y (% total impairment score, manual dexterity, balance)     Normal: 48, 62, 52     Borderline: 5, 29, 24     Motor problem: 48, 10, 24
Ostojic et al (2016)[@147107]	Serbia	Mean (SD) PedsFACIT-F total score among patients with MS 14-18 y: 39.67 (9.32)     Mean (SD) KIDSCREEN-52 (patients with MS vs healthy controls)     Physical well-being: 47.00 (11.25) vs 52.60 (11.62)     Psychological well-being: 49.82 (12.76) vs 51.19 (10.26)     Moods and emotions: 51.65 (12.48) vs 47.06 (10.27)     Self-perception: 50.74 (10.19) vs 47.83 (8.28)     Autonomy: 53.40 (10.88) vs 53.76 (11.01)     Parent relation and home life: 55.12 (9.68) vs 50.69 (9.33)     Financial resources: 51.96 (8.70) vs 50.43 (8.84)     Social support and peers: 52.91 (13.55) vs 54.57 (11.26)     School environment: 47.65 (10.24) vs 48.63 (8.97)     Social acceptance (bullying): 50.86 (12.67) vs 52.60 (9.13)
Kirk and Hinton (2019)[@147095]	UK	“The change and changeable body” emerged as the main finding and captured patients’ (8-17 y) experiences of living with an MS diagnosis: altered sense of their identity, changed relationships (particularly with mothers), and a reconfigured future (acknowledging MS would be part of their lives)
Aaen et al (2019)[@147097]	US	Walked after 15 mo (%)     Patients with MS onset <11 y: 3.7     Patients with MS onset ≥11 y: 1.8     Healthy controls: 5.7
Waldman et al (2016)[@147108]	US	Difference in composite z scores on MSFC between patients with MS 6-21 y and healthy controls (OR, P value): 0.56, 0.23
Weisbrot et al (2014)[@147109]	US	Mean (SD) CGAS in patients with MS 8-17 y     With psychiatric disorder: 58.20 (15.0)     No psychiatric disorder: 88.50 (8.1)     (P < .001)