Patients with ET Patients without ET (n-5244)
Comorbidity Overall (n=5286) Treatment Group P Valuec
Untreated (n=1374) Pharmacotherapy (n=3767) Invasive Therapy (n=145) P Valueb
Hypertension 3587 (67.86) 894 (65.07) 2611 (69.31) 82 (56.55) .0002 2981 (56.85) <.0001
Pain disorders 3269 (61.84) 738 (53.71) 2425 (64.37) 106 (73.1) <.0001 2386 (45.5) <.0001
Hyperlipidemia 2928 (55.39) 760 (55.31) 2089 (55.46) 79 (54.48) .9714 2266 (43.21) <.0001
Fatigue and sleep related disorders 1485 (28.09) 351 (25.55) 1089 (28.91) 45 (31.03) .0434 888 (16.93) <.0001
Diabetes mellitus 1444 (27.32) 324 (23.58) 1085 (28.8) 35 (24.14) .0007 1,291 (24.62) .0016
Obesity 1366 (25.84) 330 (24.02) 1004 (26.65) 32 (22.07) .0928 929 (17.72) <.0001
Osteoarthritis 1334 (25.24) 304 (22.13) 983 (26.1) 47 (32.41) .0019 972 (18.54) <.0001
Anxiety 1174 (22.21) 201 (14.63) 931 (24.71) 42 (28.97) <.0001 542 (1.34) <.0001
Chronic pulmonary disease 1076 (20.36) 240 (17.47) 809 (21.48) 27 (18.62) .0059 776 (14.8) <.0001
Depression 1065 (20.15) 198 (14.41) 834 (22.14) 33 (22.76) <.0001 540 (1.3) <.0001
Ischemic heart disease 1020 (19.3) 262 (19.07) 738 (19.59) 20 (13.79) .2148 914 (17.43) .0134
Cancer (malignant) 674 (12.75) 177 (12.88) 484 (12.85) 13 (8.97) .3827 585 (11.16) .0117
Cerebrovascular disease 649 (12.28) 177 (12.88) 456 (12.11) 16 (11.03) .6776 413 (7.88) <.0001
Chronic kidney disease 630 (11.92) 155 (11.28) 457 (12.13) 18 (12.41) .6946 561 (1.7) .0481
Peripheral vascular disease 596 (11.28) 148 (10.77) 435 (11.55) 13 (8.97) .4963 471 (8.98) <.0001
Atrial fibrillation 591 (11.18) 148 (10.77) 427 (11.34) 16 (11.03) .8498 505 (9.63) .0092
Substance use disorders 570 (10.78) 104 (7.57) 451 (11.97) 15 (10.34) <.0001 366 (6.98) <.0001
Glaucoma 474 (8.97) 108 (7.86) 358 (9.5) 8 (5.52) .0638 476 (9.08) .8439
Congestive heart failure 471 (8.91) 112 (8.15) 347 (9.21) 12 (8.28) .4799 439 (8.37) .3251
Osteoporosis 461 (8.72) 123 (8.95) 322 (8.55) 16 (11.03) .5464 298 (5.68) <.0001
Diverticular disease 365 (6.91) 92 (6.7) 262 (6.96) 11 (7.59) .899 257 (4.9) <.0001
Rheumatoid arthritis 268 (5.07) 50 (3.64) 206 (5.47) 12 (8.28) .0061 182 (3.47) <.0001
Chronic thyroid disorders 264 (4.99) 75 (5.46) 178 (4.73) 11 (7.59) .1967 796 (15.18) <.0001
Dementia 249 (4.71) 78 (5.68) 170 (4.51) 1 (0.69) .0149 185 (3.53) .0023
Iron deficiency anemia 216 (4.09) 49 (3.57) 160 (4.25) 7 (4.83) .4963 172 (3.28) .0281
Epilepsy 184 (3.48) 59 (4.29) 116 (3.08) 9 (6.21) .0211 59 (1.13) <.0001
Inflammatory bowel disease 167 (3.16) 32 (2.33) 131 (3.48) 4 (2.76) .1097 95 (1.81) <.0001
Liver disease 165 (3.12) 34 (2.47) 129 (3.42) 2 (1.38) .1054 134 (2.56) .0803
Bipolar disorder 163 (3.08) 23 (1.67) 134 (3.56) 6 (4.14) .0019 51 (.97) <.0001
Kidney stones 159 (3.01) 43 (3.13) 109 (2.89) 7 (4.83) .3898 94 (1.79) <.0001