TOPS™	Control
Time Horizon	Costa	QALY	Cost	QALY	∆Costb	∆QALYc	ICER,d $ per QALY
Health systems
90-day	$41 513	0.1759	$40 032	0.1697	$1481	0.0063	$236 407
1-year	$43 445	0.7171	$42 409	0.7003	$1036	0.0169	$61 446
2-year (base case)	$44 763	1.4142	$44 462	1.3653	$300	0.0489	$6158
6-year (extrapolated)	$49 349	4.0382	$56 076	3.6848	-$6727	0.3534	Dominant
10-year (extrapolated)	$53 320	6.3865	$68 867	5.6009	-$15 546	0.7856	Dominant
Societal
90-day	$41 769	0.1759	$40 419	0.1697	$1349	0.0063	$215 357
1-year	$45 170	0.7171	$44 742	0.7003	$427	0.0169	$25 377
2-year (base case)	$48 330	1.4142	$50 162	1.3653	-$1832	0.0489	Dominant
6-year (extrapolated)	$58 608	4.0382	$81 771	3.6848	-$23 162	0.3534	Dominant
10-year (extrapolated)	$67 075	6.3865	$118 371	5.6009	-$51 296	0.7856	Dominant