Descriptive Outcomes in Follow-up Period (36 months)	Fall/Fracture Cohort (n = 3886)
Fall/fracture characteristics
Falls
Patients with ≥1 fall, n (%)	1349 (34.7%)
Total number of falls per patient, mean ± SD [median]	3.0 ± 2.1 [2]
Proportion of falls associated with hospitalization, %	27.7%
Fractures
Patients with ≥1 fracture, n (%)	3299 (84.9%)
Total number of fractures per patient, mean ± SD [median]	8.3  ±  11.6 [4]
Fractures by location
Hip
Patients with ≥1 hip fracture, n (%)	485 (12.5%)
Total number of hip fractures per patient, mean ± SD [median]	7.0 ± 7.6 [4]
Spine
Patients with ≥1 spine fracture, n (%)	613 (15.8%)
Total number of spine fractures per patient, mean ± SD [median]	6.1 ± 7.7 [4]
Non-hip/non-spine
Patients with ≥1 non-hip/non-spine fracture, n (%)	2820 (72.6%)
Total number of non-hip/non-spine fractures per patient, mean ± SD [median]	7.7 ± 11.1 [4]
Fractures resulting in hospitalization
All fractures
Proportion of fractures associated with hospitalization, %	13.5%
Patients with ≥1 fracture associated with hospitalization, n (%)	1052 (27.1%)
Total number of fracture(s) associated with hospitalization per patient, mean ± SD [median]	3.5 ± 4.3 [2]
Hip
Proportion of hip fractures associated with hospitalization, %	35.7%
Patients with ≥1 hip fracture associated with hospitalization, n (%)	332 (8.5%)
Total number of hip fracture(s) associated with hospitalization per patient, mean ± SD [median]	3.6 ± 3.1 [3]
Spine
Proportion of spine fractures associated with hospitalization, %	20.4%
Patients with ≥1 spine fracture associated with hospitalization, n (%)	241 (6.2%)
Total number of spine fracture(s) associated with hospitalization per patient, mean ± SD [median]	3.1 ± 2.0 [2]
Non-hip/non-spine
Proportion of non-hip/non-spine fractures associated with hospitalization, %	12.2%
Patients with ≥1 non-hip/non-spine fracture associated with hospitalization, n (%)	772 (19.9%)
Total number of non-hip/non-spine fracture(s) associated with hospitalization per patient, mean ± SD [median]	3.5 ± 4.4 [3]
Drug use characteristics
Opioid
Cumulative dose (in MME) in 30 days preceding fall/fracture, mean ± SD [median]	2376.7 ± 12 863.4 [886]
Opioid molecules, ≥1 prescription in 30 days preceding fall/fracture, n (%)	2212 (56.9%)
Tramadol
IR	488 (12.6%)
ER	24 (0.6%)
Non-tramadol opioids
IR	1694 (43.6%)
ER	448 (11.5%)
Sedative-hypnotics
≥1 benzodiazepine prescription in 30 days preceding fall/fracture, n (%)	559 (14.4%)
No. of benzodiazepine prescriptions in 30 days preceding fall/fracture, mean ± SD [median]	1.1 ± 0.4 [1]
≥1 insomnia drug prescription in 30 days preceding fall/fracture, n (%)	0 (0.0%)
No. of insomnia drug prescriptions in 30 days preceding fall/fracture, mean ± SD [median]	—