Pain Medication Baselineb 12-Month Follow-up 24-Month Follow-up
MTS Non-MTS SD MTS Non-MTS Std Diff MTS Non-MTS Std Diff
Any 143 492
(77.0)*		 127 212
(68.3)		 -0.20 166 943
(89.6)*		 141 848
(76.1)		 -0.36 175 246
(94.0)*		 158 505
(85.1)		 -0.30
Analgesics/antipyretics 14 910
(8.0)*		 11 646
(6.3)		 -0.07 18 522
(9.9)*		 12 572
(6.8)		 -0.12 27 378
(14.7)*		 19 811
(10.6)		 -0.12
NSAIDs/COX-2 inhibitors 73 608
(39.5)* 		60 158
(32.3) 		-0.15 98 725
(53.0)* 		74 930
(40.2) 		-0.26 117 340
(63.0)* 		94 956
(51.0) 		-0.24
IA corticosteroids/HA 23 952
(12.9)* 		16 299
(8.8)		 -0.13 55 948
(30.0)* 		30 719
(16.5) 		-0.32 68 327
(36.7)* 		41 724
(22.4) 		-0.32
Tramadol 25 316
(13.6)* 		16 098
(8.6)		 -0.16 39 154
(21.0)* 		18 743
(10.1) 		-0.31 51 085
(27.4)* 		28 310
(15.2) 		-0.30
Non-tramadol opioids 76 721
(41.2)* 		53 226
(28.6) 		-0.27 106 343
(57.1)* 		54 634
(29.3) 		-0.58 127 690
(68.5)* 		79 160
(42.5) 		-0.54
Antidepressants 52 659
(28.3)* 		40 370
(21.7) 		-0.15 55 425
(29.7)* 		43 103
(23.1) 		-0.15 63 818
(34.2)* 		50 879
(27.3) 		-0.15
Muscle relaxants 28 697
(15.4)* 		21 477
(11.5) 		-0.11 32 414
(17.4)* 		22 551
(12.1) 		-0.15 46 237
(24.8)* 		34 449
(18.5) 		-0.15
Benzodiazepines 43 376
(23.3)* 		33 415
(17.9) 		-0.13 51 008
(27.4)* 		36 085
(19.4) 		-0.19 67 068
(36.0)* 		51 337
(27.6) 		-0.18
Anxiolytics/sedatives/hypnotics 21 787
(11.7)* 		15 540
(8.3)		 -0.11 23 122
(12.4)* 		15 287
(8.2) 		-0.14 30 177
(16.2)* 		20 709
(11.1) 		-0.15
Anticonvulsants 40 745
(21.9)* 		31 352
(16.8) 		-0.13 53 300
(28.6)* 		36 842
(19.8) 		-0.21 72 412
(38.9)* 		54 643
(29.3) 		-0.20