Study Region/ Country Study Type Study Design Age Study Period Total WD, n Eligibility Criteria Study Objective QOL/HRQOL Measurement Used
Schaefer et al (2016)[@95748] Germany Full-text Retrospective-cross sectional study ≥18 -- 68 All patients included had confirmed diagnosis of WD, attended our tertiary WD care center, and were 18 years of age or older. Patients receiving antipsychotic or antidepressant co-medication and patients who underwent liver transplantation for WD were excluded from the study. Measure the QOL in WD patients and compare QOL across gender and treatment regimen SF-36
Carta et al (2012)[@95749] Italy Full-text Case-control study -- -- 23 Patients diagnosed and treated for WD Compare and evaluate the impairment of quality of life between individuals with WD and individuals without. Moreover, assess the relationship between mood disorders and impaired quality of life in WD through SF-12
Svetel et al (2011)[@95750] Serbia Full-text Cross-sectional study -- -- 60 Patients with WD recruited from the WD Clinical Research Program at the University of Belgrade who were clinically stable (no significant clinical change in the preceding 6 months) and had been on standardized therapy for WD for at least 2 years (ie, at the time of investigation, all patients were in a copper-depleted state) Measure the QOL in WD patients SF-36
Aggarwal et al (2009)[@95752] India Full-text Prospective study All ages 2006-2007 30 -- -- GAS
Komal Kumar et al (2007)[@95753] India Full-text Retrospective study >18 -- 30 Patients were selected from a large cohort of WD, followed at a tertiary care University teaching hospital, from south India. Inclusion criteria for the study were the definite diagnosis of WD and treatment. Patients who were unable to answer the questionnaire due to behavioral problems, low IQ or other disease related factors per se were excluded. Measure the QOL in WD patients WHO-QOL-BREF
Sutcliffe et al (2003)[@95751] UK Full-text Prospective study All ages 1988-2000 21 Patients diagnosed with WD and underwent orthotopic liver transplantation Assess quality of life in a group of individuals diagnosed with WD whom had undergone liver transplantation SF-36
Camarata et al (2021)[@95754] USA and Europe Full-text Cross-sectional study >18 2017-2020 62 Patients diagnosed and treated for WD To assess the QOL of patients with WD and the relationship between mental and physical health QOL and severity of liver disease, neurological disease, and the most common psychiatric problems in patients with WD: major depressive disorder (MDD) and cognitive impairment. SF-12