Variable Count, n (%) Patients with FN: First Chemotherapy Cycle, n (%) Patients with FN: All Chemotherapy Cycles, n (%)
Main Definition Sensitive Definition Specific Definition Main Definition Sensitive Definition Specific Definition
Total Population 4460 (100) 183 (4.10) 61 (1.37) 57 (1.28) 574 (3.65) 163 (1.04) 149 (0.95)
US Region
North Central 921 (20.65) 38 (4.13) 13 (1.41) 13 (1.41) 129 (4.01) 35 (1.09) 32 (1.00)
Northeast 721 (16.17) 39 (5.41) 11 (1.53) 10 (1.39) 121 (4.98) 32 (1.32) 27 (1.11)
South 2252 (50.49) 83 (3.69) 30 (1.33) 29 (1.29) 253 (3.15) 68 (0.85) 67 (0.83)
West 566 (12.69) 23 (4.06) 7 (1.24) NRa 71 (3.46) 28 (1.36) 23 (1.12)
Insurance Type
Commercial 4157 (93.21) 168 (4.04) 53 (1.27) 49 (1.18) 535 (3.65) 148 (1.01) 135 (0.92)
Medicare 303 (6.79) 15 (4.95) 8 (2.64) 8 (2.64) 39 (3.73) 15 (1.43) 14 (1.34)
Regimen Risk Level
High 3727 (83.57) 139 (3.73) 44 (1.18) 41 (1.10) 491 (3.48) 136 (0.96) 124 (0.88)
Intermediate 667 (14.96) 41 (6.15) 16 (2.40) 15 (2.25) 75 (5.40) 24 (1.73) 22 (1.58)
Otherb 66 (1.48) NRa NRa NRa 8 (3.96) NRa NRa
Quan-Charlson Comorbidity Score
1–2 1687 (35.09) 62 (3.98) 17 (1.09) 16 (1.03) 199 (3.49) 46 (0.81) 44 (0.77)
3–4 800 (16.64) 28 (4.17) 9 (1.34) 7 (1.04) 84 (3.66) 21 (0.92) 16 (0.70)
5+ 2321 (48.27) 93 (4.17) 35 (1.57) 34 (1.52) 291 (3.76) 96 (1.24) 89 (1.15)
Days between Chemotherapy and Pegfilgrastim Administration
D0 1974 (44.26) 92 (4.66) 25 (1.27) 25 (1.27) 278 (4.08) 63 (0.92) 56 (0.82)
D1 2340 (52.47) 85 (3.63) 33 (1.41) 31 (1.32) 279 (3.29) 96 (1.13) 91 (1.07)
D2+ 146 (3.27) 6 (4.11) NRa NRa 17 (4.02) NRa NRa
Metastatic Disease to the Bone
No 4459 (99.98) 183 (4.10) 61 (1.37) 57 (1.28) 574 (3.65) 163 (1.04) 149 (0.95)
Yes NRa 0 (0.00) 0 (0.00) 0 (0.00) 0 (0.00) 0 (0.00) 0 (0.00)
Baseline Radiation
No 4313 (96.70) 177 (4.10) 59 (1.37) 55 (1.28) 546 (3.59) 156 (1.03) 142 (0.93)
Yes 147 (3.30) NRa NRa NRa 28 (5.43) 7 (1.36) 7 (1.36)
Recent Surgery
No 714 (16.01) 31 (4.34) 9 (1.26) 8 (1.12) 88 (3.78) 19 (0.82) 18 (0.77)
Yes 3746 (83.99) 152 (4.06) 52 (1.39) 49 (1.31) 486 (3.63) 144 (1.08) 131 (0.98)
Baseline Liver Dysfunction
No 4139 (92.80) 162 (3.91) 55 (1.33) 52 (1.26) 509 (3.49) 152 (1.04) 141 (0.97)
Yes 321 (7.20) 21 (6.54) NRa NRa 65 (5.77) 11 (0.98) 8 (0.71)
Baseline Renal Dysfunction
No 4344 (97.40) 177 (4.07) 59 (1.36) 52 (1.26) 551 (3.60) 154 (1.01) 141 (0.92)
Yes 116 (2.60) NRa NRa NRa 23 (5.45) 9 (2.13) 8 (1.90)
History of Persistent Neutropenia
No 4440 (99.55) 165 (3.72) 60 (1.35) 56 (1.26) 518 (3.31) 162 (1.04) 148 (0.95)
Yes 20 (0.45) 18 (90.00) NRa NRa 56 (76.71) NRa NRa
Age ≥65 Years Old
No 4114 (92.24) 167 (4.06) 52 (1.26) 48 (1.17) 530 (3.65) 145 (1.00) 132 (0.91)
Yes 346 (7.76) 16 (4.62) 9 (2.60) 9 (2.60) 44 (3.66) 18 (1.50) 17 (1.41)