Variable
|
Count, n (%)
|
Patients with FN: First Chemotherapy Cycle, n (%)
|
Patients with FN: All Chemotherapy Cycles, n (%)
|
Main Definition
|
Sensitive Definition
|
Specific Definition
|
Main Definition
|
Sensitive Definition
|
Specific Definition
|
Total Population
|
4460 (100)
|
183 (4.10)
|
61 (1.37)
|
57 (1.28)
|
574 (3.65)
|
163 (1.04)
|
149 (0.95)
|
US Region
|
North Central
|
921 (20.65)
|
38 (4.13)
|
13 (1.41) |
13 (1.41)
|
129 (4.01) |
35 (1.09)
|
32 (1.00) |
Northeast
|
721 (16.17)
|
39 (5.41)
|
11 (1.53) |
10 (1.39)
|
121 (4.98) |
32 (1.32)
|
27 (1.11) |
South
|
2252 (50.49)
|
83 (3.69)
|
30 (1.33) |
29 (1.29)
|
253 (3.15) |
68 (0.85)
|
67 (0.83) |
West
|
566 (12.69)
|
23 (4.06)
|
7 (1.24) |
NRa
|
71 (3.46) |
28 (1.36)
|
23 (1.12) |
Insurance Type
|
Commercial
|
4157 (93.21)
|
168 (4.04)
|
53 (1.27) |
49 (1.18)
|
535 (3.65) |
148 (1.01)
|
135 (0.92) |
Medicare
|
303 (6.79)
|
15 (4.95)
|
8 (2.64) |
8 (2.64)
|
39 (3.73) |
15 (1.43)
|
14 (1.34) |
Regimen Risk Level
|
High
|
3727 (83.57)
|
139 (3.73)
|
44 (1.18) |
41 (1.10)
|
491 (3.48) |
136 (0.96)
|
124 (0.88) |
Intermediate
|
667 (14.96)
|
41 (6.15)
|
16 (2.40) |
15 (2.25)
|
75 (5.40) |
24 (1.73)
|
22 (1.58) |
Otherb
|
66 (1.48)
|
NRa
|
NRa
|
NRa
|
8 (3.96)
|
NRa
|
NRa
|
Quan-Charlson Comorbidity Score
|
1–2
|
1687 (35.09)
|
62 (3.98)
|
17 (1.09) |
16 (1.03)
|
199 (3.49) |
46 (0.81)
|
44 (0.77) |
3–4
|
800 (16.64)
|
28 (4.17)
|
9 (1.34) |
7 (1.04)
|
84 (3.66) |
21 (0.92)
|
16 (0.70) |
5+
|
2321 (48.27)
|
93 (4.17)
|
35 (1.57) |
34 (1.52)
|
291 (3.76) |
96 (1.24)
|
89 (1.15) |
Days between Chemotherapy and Pegfilgrastim Administration
|
D0
|
1974 (44.26)
|
92 (4.66)
|
25 (1.27) |
25 (1.27)
|
278 (4.08) |
63 (0.92)
|
56 (0.82) |
D1
|
2340 (52.47)
|
85 (3.63)
|
33 (1.41) |
31 (1.32)
|
279 (3.29) |
96 (1.13)
|
91 (1.07) |
D2+
|
146 (3.27)
|
6 (4.11)
|
NRa
|
NRa
|
17 (4.02) |
NRa
|
NRa
|
Metastatic Disease to the Bone
|
No
|
4459 (99.98)
|
183 (4.10)
|
61 (1.37) |
57 (1.28)
|
574 (3.65) |
163 (1.04)
|
149 (0.95) |
Yes
|
NRa
|
0 (0.00)
|
0 (0.00) |
0 (0.00)
|
0 (0.00)
|
0 (0.00)
|
0 (0.00) |
Baseline Radiation
|
No
|
4313 (96.70)
|
177 (4.10)
|
59 (1.37) |
55 (1.28)
|
546 (3.59) |
156 (1.03)
|
142 (0.93) |
Yes
|
147 (3.30)
|
NRa
|
NRa
|
NRa
|
28 (5.43) |
7 (1.36)
|
7 (1.36) |
Recent Surgery
|
No
|
714 (16.01)
|
31 (4.34)
|
9 (1.26) |
8 (1.12)
|
88 (3.78) |
19 (0.82)
|
18 (0.77) |
Yes
|
3746 (83.99)
|
152 (4.06)
|
52 (1.39) |
49 (1.31)
|
486 (3.63) |
144 (1.08)
|
131 (0.98) |
Baseline Liver Dysfunction
|
No
|
4139 (92.80) |
162 (3.91)
|
55 (1.33) |
52 (1.26)
|
509 (3.49) |
152 (1.04) |
141 (0.97) |
Yes
|
321 (7.20) |
21 (6.54)
|
NRa
|
NRa
|
65 (5.77) |
11 (0.98) |
8 (0.71) |
Baseline Renal Dysfunction
|
No
|
4344 (97.40) |
177 (4.07)
|
59 (1.36) |
52 (1.26)
|
551 (3.60) |
154 (1.01) |
141 (0.92) |
Yes
|
116 (2.60) |
NRa
|
NRa
|
NRa
|
23 (5.45) |
9 (2.13) |
8 (1.90) |
History of Persistent Neutropenia
|
No
|
4440 (99.55) |
165 (3.72)
|
60 (1.35) |
56 (1.26)
|
518 (3.31) |
162 (1.04) |
148 (0.95) |
Yes
|
20 (0.45) |
18 (90.00)
|
NRa
|
NRa
|
56 (76.71) |
NRa
|
NRa
|
Age ≥65 Years Old
|
No
|
4114 (92.24) |
167 (4.06)
|
52 (1.26) |
48 (1.17)
|
530 (3.65) |
145 (1.00) |
132 (0.91) |
Yes
|
346 (7.76) |
16 (4.62)
|
9 (2.60) |
9 (2.60)
|
44 (3.66) |
18 (1.50) |
17 (1.41) |