Pre-Intervention Trend		Post-Intervention Change in Trend
N=74 532	IRR (95% CI)	P-value	IRR (95% CI)	P-value
Utilization Outcomes
Primary care visit	1.00 (0.99-1.00)	0.168	0.99 (0.98-0.99)	<0.001
Hospital outpatient visit	1.00 (0.98-1.04)	0.530	0.97 (0.94-1.01)	0.101
Emergency department visit	1.00 (0.99-1.01)	0.750	1.00 (0.98-1.02)	0.915
Hematology visit	1.00 (0.98-1.01)	0.563	1.00 (0.97-1.03)	0.973
Inpatient hospitalization	1.00 (1.00-1.01)	0.261	1.00 (0.98-1.01)	0.306
Nurse practitioner visit	1.04 (1.02-1.07)	0.003	0.98 (0.95-1.00)	0.074
Physician assistant visit	1.02 (0.99-1.05)	0.171	0.98 (0.95-1.00)	0.058
Prescription Utilization Outcomes
Hydroxyurea fill	1.00 (1.00-1.01)	0.056	1.00 (1.00-1.01)	0.637
Opioid fill	0.99 (0.99-0.98)	0.005	1.01 (1.00-1.02)	0.006
	Coef. (95% CI)	P-value	Coef. (95% CI)	P-value
Expenditure Outcomes
Primary care	0.05 (-0.08, 0.18)	0.450	-0.24 (-0.66, 0.17)	0.220
Hospital outpatient	0.3 (-0.32, 0.93)	0.310	-0.6 (-1.46, 0.26)	0.160
Emergency department	0.65 (-0.76, 2.07)	0.330	-0.83 (-3.31, 1.66)	0.480
Hematology	-0.06 (-0.25, 0.12)	0.460	0.13 (-0.16, 0.42)	0.340
Inpatient hospitalization	0.12 (-2.09, 2.34)	0.900	-0.26 (-3.09, 2.58)	0.850
Nurse practitioner	0.24 (0.09, 0.39)	0.000	-0.08 (-0.24, 0.07)	0.260
Physician assistant	0.08 (-0.05, 0.21)	0.190	-0.09 (-0.23, 0.05)	0.190
Prescription Expenditure Outcomes
Hydroxyurea	-0.05 (-0.12, 0.01)	0.070	0.07 (-0.05, 0.19)	0.240
Opioid	0.06 (-0.25, 0.37)	0.670	0.01 (-0.20, 0.23)	0.910
Total Expenditures
Total	1.35 (-1.68, 4.39)	0.35	-1.71 (-5.30, 1.88)	0.32