Total Claims	Pre-Intervention	Post-Intervention
	N=74 541	n=45 346	n=29 195
Patient Claims Characteristics
Sex, n (%)
Female	41 918 (56.2%)	25 678 (56.6%)	16 240 (55.6%)
Male	32 623 (43.8%)	19 668 (43.4%)	12 955 (44.4%)
Age, mean (SD)	17.99 (13.45)	18.21 (13.45)	17.66 (13.45)
Age, median (IQR)	15.00 (8.00-25.00)	15.00 (8.00-25.00)	15.00 (7.00-25.00)
CCNC program months enrolled, mean (SD)	0.93 (0.23)	0.93 (0.22)	0.92 (0.25)
Median (IQR)	1.00 (1.00-1.00)	1.00 (1.00-1.00)	1.00 (1.00-1.00)
Aggregate Monthly Spending on Endari
Average Monthly Endari Spending ($1000s), mean (SD)	31.10 (34.37)	6.46 (17.41)	69.38 (11.69)
Average Monthly Endari Spending ($1000s), median (IQR)	10.01 (0.00-70.15)	0.00 (0.00-0.00)	70.58 (70.15- 78.27)
Residence Claims Characteristics
Residence, n (%)
Metro	59 003 (79.2%)	35 981 (79.3%)	23 022 (78.9%)
Non-Metro adjacent to metro	13 553 (18.2%)	8271 (18.2%)	5282 (18.1%)
Non-Metro un-adjacent to metro	1985 (2.7%)	1094 (2.4%)	891 (3.1%)
CCNC network, n (%)
1	14 341 (19.2%)	8499 (18.7%)	5842 (20.0%)
2	6400 (8.6%)	3547 (7.8%)	2853 (9.8%)
3	5083 (6.8%)	2937 (6.5%)	2146 (7.4%)
4	2759 (3.7%)	2311 (5.1%)	448 (1.5%)
5	4234 (5.7%)	2815 (6.2%)	1419 (4.9%)
6	3463 (4.6%)	1970 (4.3%)	1493 (5.1%)
7	8339 (11.2%)	4777 (10.5%)	3562 (12.2%)
8	686 (0.9%)	406 (0.9%)	280 (1.0%)
9	12 519 (16.8%)	6951 (15.3%)	5568 (19.1%)
10	5007 (6.7%)	3197 (7.1%)	1810 (6.2%)
11	5193 (7.0%)	3925 (8.7%)	1268 (4.3%)
12	6517 (8.7%)	4011 (8.8%)	2506 (8.6%)