Criteria	Description
Population	Infants with infantile spasms; age: 2-24 months Infantile spasms is a rare disorder characterized by distinct seizures and a representative electroencephalographic (EEG) pattern known as hypsarrhythmia.
Intervention	Repository corticotropin injection
Comparator(s)	Two comparators were assessed separately. Synthetic ACTH_1-24 (tetracosactide) Synthetic ACTH_1-39 (corticotropin carboxymethyl-cellulose)
Outcomes	Efficacy outcomes were assessed at 2-4 weeks of follow-up. Efficacy outcomes comprised: Cessation of spasms was defined as no observed spasms based on clinical criteria, either reported by parents or trained observers. Resolution of hypsarrhythmia was evaluated based on video EEG monitoring. Paired outcome comprising both cessation of spasms and resolution of hypsarrhythmia.
Study Design	Controlled/trial studies

Population

Infants with infantile spasms; age: 2-24 months Infantile spasms is a rare disorder characterized by distinct seizures and a representative electroencephalographic (EEG) pattern known as hypsarrhythmia.

Intervention

Repository corticotropin injection

Comparator(s)

Two comparators were assessed separately.

Synthetic ACTH_1-24 (tetracosactide)
Synthetic ACTH_1-39 (corticotropin carboxymethyl-cellulose)

Outcomes

Efficacy outcomes were assessed at 2-4 weeks of follow-up. Efficacy outcomes comprised:

Cessation of spasms was defined as no observed spasms based on clinical criteria, either reported by parents or trained observers.
Resolution of hypsarrhythmia was evaluated based on video EEG monitoring.
Paired outcome comprising both cessation of spasms and resolution of hypsarrhythmia.

Study Design

Controlled/trial studies