| Model Base Case Results for Time Horizon of 20 Years |
Model Simulation Based on PV Population with HU Treatment in PROUD/COUTINUATION |
General Population |
Model Simulations for JAK2 Subgroups |
|
|
|
|
JAK2 <50%
|
JAK2 ≥50%
|
| Disease Progression (%) |
|
|
|
|
| Acute leukemia |
3.98 |
- |
4.42 |
3.04 |
| Myelofibrosis |
11.88 |
- |
2.06 |
29.30 |
| Thrombosis |
30.40 |
- |
25.84 |
37.63 |
| Overall Survival (LY) |
16.6 |
18.5 |
17.1 |
15.3 |