|
(N = 8521)
|
|
|
Baseline Clinical Characteristics
|
N/Mean
|
%/SD
|
|
Charlson Comorbidity Index (CCI) Score
|
0.65 |
1.25 |
| 0 |
5665 |
66.5% |
| 1 |
1593 |
18.7% |
| 2–3 |
941 |
11.0% |
| 4+ |
322 |
3.8% |
|
Patients With Baseline VOC Episodes
|
2097 |
24.6% |
|
Baseline Number of VOC Episodes (6 months)
|
1.04 |
2.72 |
|
Individual Comorbid Conditions*
|
|
|
| Neoplasms benign and malignant |
617 |
7.2% |
| Seizures |
393 |
4.6% |
| Asthma |
928 |
10.9% |
| Upper respiratory tract infections |
565 |
6.6% |
| Acute chest syndrome |
233 |
2.7% |
| Infectious and parasitic diseases |
1682 |
19.7% |
| Fever |
792 |
9.3% |
| Constipation |
501 |
5.9% |
| Chronic pain |
418 |
4.9% |
| Iron overload |
367 |
4.3% |
| Aseptic (avascular) bone necrosis |
359 |
4.2% |
|
Baseline SCD Management
|
|
|
|
SCD Medication*
|
|
|
| Antibiotics |
3819 |
44.8% |
| Acetaminophen |
3756 |
44.1% |
| Folic acid |
2542 |
29.8% |
| Opioids (narcotics) |
2393 |
28.1% |
| NSAIDs |
2214 |
26.0% |
| Hydroxyurea |
921 |
10.8% |
|
Other SCD Management*
|
|
|
| Blood transfusions |
1189 |
14.0% |
|
Baseline All-Cause Health Care Resource*
|
|
|
| Any pharmacy visit |
7266 |
85.3% |
| Any outpatient hospital visit |
5992 |
70.3% |
| Any outpatient office visit |
5923 |
69.5% |
| Any outpatient ER visit |
4563 |
53.6% |
| Any outpatient other visit |
3580 |
42.0% |
| Any lab visit |
3318 |
38.9% |
| Any inpatient stay |
2543 |
29.8% |