Total Costs (€)				Total QALYs				ICER, €/QALY
	LGS		DS		LGS		DS		LGS	DS
	CBD	Usual Care	CBD	Usual Care	CBD	Usual Care	CBD	Usual Care
Base case	2 365 876	2 337 538	2 222 650	2 246 291	6.749	5.431	15.813	14.944	21 493	Dominating
Applied a 2023 cost year	2 686 073	2 667 187	2 507 247	2 545 925	6.749	5.431	15.813	14.944	14 324	Dominating
Healthcare perspective (excludes replacement costs)	1 084 229	1 010 424	983 386	937 731	6.749	5.431	15.813	14.944	55 978	52570
Applied 12-17 y group weight to the 18-55 y group (DS only)	N/A	N/A	2 236 433	2 255 965	N/A	N/A	15.813	14.944	N/A	Dominating
Assume patients in both model arms remain in their health states following Cycle 1	2 381 055	2 337 538	2 216 519	2 246 291	6.627	5.431	15.903	14.944	36 380	Dominating
Alternative seizure thresholdsa,b	2 341 096	2 309 790	2 205 285	2 220 720	5.259	4.282	16.187	15.511	32 051	Dominating
Relative treatment effect is not maintained	2 367 967	2 344 732	2 246 248	2 324 616	6.402	4.644	15.591	14.345	13 216	Dominating
Target population: starting age of 2 y	3 311 261	3 310 538	2 889 889	2 951 745	6.982	5.652	16.326	15.448	543	Dominating
Mean weight of adults assumed the same as the 12-17 y age group (DS only)	N/A	N/A	2 236 433	2 255 965	N/A	N/A	15.813	14.944	N/A	Dominating
Time horizon: 20 y	1 761 516	1 730 599	1 629 781	1 646 102	3.943	2.859	8.464	7.833	28 538	Dominating
Time horizon: 30 y	2 040 740	2 010 982	1 901 404	1 921 581	4.940	3.748	10.996	10.259	24 969	Dominating
No. of caregivers: 2	2 365 876	2 337 538	2 222 650	2 246 291	-15.438	−18.863	7.378	5.424	8272	Dominating
Utilities associated with non-drop seizures included (LGS only)	2 365 876	2 337 538	N/A	N/A	3.387	1.917	N/A	N/A	19 281	N/A
Utilities associated with non-convulsive seizures included (DS only)	N/A	N/A	2 222 650	2 246 291	N/A	N/A	13.430	12.312	N/A	Dominating
Mortality RR in seizure-free health states: 0.71	2 372 579	2 337 538	2 241 455	2 252 557	6.831	5.431	16.191	15.132	25 028	Dominating
Varied proportion for ICU admissions within hospitalizations: 50% in general ward vs 50% in ICU	2 380 252	2 353 686	2 247 975	2 275 288	6.749	5.431	15.813	14.944	20 150	Dominating
10% long-term discontinuation rate applied to seizure health states	2 345 962	2 337 538	2 211 322	2 246 291	6.526	5.431	15.748	14.944	7693	Dominating
Lag discontinuation applied for 6 months	2 372 464	2 337 538	2 228 066	2 246 291	6.749	5.431	15.813	14.944	26 490	Dominating
Varied AE disutilities: doubling	2 365 876	2 337 538	2 222 650	2 246 291	6.749	5.431	15.811	14.944	21 500	Dominating
Varied AE disutilities: tripling	2 365 876	2 337 538	2 222 650	2 246 291	6.749	5.431	15.810	14.944	21 506	Dominating
Varied AE costs: doubling	2 365 985	2 337 582	2 222 838	2 246 390	6.749	5.431	15.813	14.944	21 543	Dominating
Varied AE costs: tripling	2 366 095	2 337 627	2 223 027	2 246 489	6.749	5.431	15.813	14.944	21 592	Dominating
No. of cycles for which AE disutilities were applied: 9 cycles	2 365 876	2 337 538	2 222 650	2 246 291	6.748	5.431	15.807	14.944	21 523	Dominating
Utility source: DS utilities (time trade-off values)	2 365 876	2 337 538	N/A	N/A	9.418	8.231	N/A	N/A	23 867	N/A
Utility source: LGS utilities (time trade-off values)	N/A	N/A	2 222 650	2 246 291	N/A	N/A	10.849	9.484	N/A	Dominating
Applied resource use estimates from the literature	2 406 702	2 376 848	2 212 870	2 232 014	6.749	5.431	15.813	14.944	22 643	Dominating
Applied same hours of care for seizure health states	2 326 838	2 287 990	2 185 668	2 199 483	6.749	5.431	15.813	14.944	29 465	Dominating
Applied same percentage of patients institutionalized for seizure-free and least severe seizure health states	2 183 066	2 159 546	2 079 448	2 092 754	6.749	5.431	15.813	14.944	17 839	Dominating