Lennox-Gastaut Syndrome				Dravet Syndrome
Demographic characteristics at baseline (n = 10 000)a
Age group, y	2–5	6–11	12–17	18–55	2–5	6–11	12–17	18–55
Proportion of patients, % (SE)	13 (0.03)	36 (0.07)	25 (0.05)	26 (0.05)	30 (0.06)	39 (0.08)	29 (0.06)	2 (0.00)
Mean weight, kg (SE)	17.9 (0.87)	28.7 (1.34)	51.4 (2.67)	59.7 (2.65)	18.2 (0.53)	30.5 (1.14)	55.0 (2.27)	49.3 (2.27)
Age group	≥2 years				≥2 years
Mean age, y (SE)	13.2 (2.63)				11.5 (2.30)
Health state allocation at baseline: No. of seizures per 3 months	≤55 drop seizures		>55 drop seizures		≤12 convulsive seizures		>12 convulsive seizures
Proportion of patients, % (SE)	38 (0.08)		62 (0.12)		50 (0.10)		50 (0.10)
Sub-health state allocation at baseline: No. of days without seizures per 3 months	No. of days without drop seizures per month (SE)				No. of days without convulsive seizures per month (SE)
	≤15 days	>15 days	≤15 days	>15 days	≤18 days	>18 days	≤18 days	>18 days
Proportion of patients, % (SE)	81 (0.16)	19 (0.04)	99 (0.20)	1 (0.00)	1 (0.00)	99 (0.20)	79 (0.16)	21 (0.04)
Resource use, %
ASM	Value	SE	Lower bound	Upper bound	Value	SE	Lower bound	Upper bound
Clobazam	100	0.20	100.00	100.00	100	0.20	100.00	100.00
Clonazepam	5	0.01	3.27	7.22	7	0.01	4.20	9.30
Levetiracetam	35	0.07	21.88	49.04	20	0.04	12.83	28.54
Rufinamide	28	0.06	17.79	39.71	5	0.01	3.16	6.98
Stiripentol	0	0.00	0.00	0.00	44	0.09	27.26	61.51
Topiramate	14	0.03	9.00	19.97	22	0.04	13.85	30.83
Valproate sodium	0	0.00	0.00	0.00	22	0.04	13.85	30.83
Valproic acid	24	0.05	15.36	34.22	64	0.13	37.46	86.69
Zonisamide	12	0.03	7.94	17.59	11	0.02	6.99	15.48
Cost of care and hours of care per weekb
	Health state		Age group of patients with LGS		Health state		Age group of patients with DS
			2-17 y	18-55 y			2-17 y	18-55 y
Hours of family care per week (SE) (€14.95 [replacement cost] per hour)	Seizure-free		34.0 (6.8)	6.8 (1.4)	Seizure-free		30.9 (6.2)	6.2 (1.2)
	≤55 seizures		67.5 (13.5)	13.5 (2.7)	≤12 seizures		61.3 (12.3)	12.3 (2.5)
	>55 seizures		72.1 (14.4)	14.4 (2.9)	>12 seizures		66.1 (13.2)	13.2 (2.6)
Hours of professional care per week (SE) (€53.40 per hour)	Seizure-free		22.7 (4.5)	4.5 (0.9)	Seizure-free		20.6 (4.1)	4.1 (0.8)
	≤55 seizures		45.0 (9.0)	9.0 (1.8)	≤12 seizures		40.9 (8.2)	8.2 (1.6)
	>55 seizures		48.1 (9.6)	9.6 (1.9)	>12 seizures		44.1 (8.8)	8.8 (1.8)
Utility valuesc
No. of seizures per month	No. of days without drop seizures per month (SE)				No. of days without convulsive seizures per month (SE)
	≤15 days		>15 days		≤18 days		>18 days
Seizure-free	N/A		0.754 (0.037)		N/A		0.778 (0.023)
≤55 drop seizures (LGS); ≤12 convulsive seizures (DS)	0.375 (0.000)		0.565 (0.047)		0.000 (0.000)		0.690 (0.028)
>55 drop seizures (LGS); >12 convulsive seizures (DS)	−0.037 (0.062)		0.153 (0.063)		0.267 (0.053)		0.437 (0.000)