| Prevalence of influenza |
Flu_prev |
uniform |
0.259 |
0.2-0.426 |
Calculated from [2] |
| Additional revenue per day due to NI |
cRev_day |
triangular |
€233.46 |
±20% (€186.77–€280.15) |
Calculated from InEK data [5] |
| Combined Sofia® specificity |
Sofia_spec |
uniform |
0.953 |
95% CI (0.915–0.992) |
[8] |
|
Opportunity costs due to
blocking twin bed
|
cOpp |
triangular |
€350.19 |
±20% (€280.15–€420.23) |
Calculated from InEK data [5] |
| Probability of correctly excluding non-influenza by clinical judgement |
Clin_spec |
uniform |
0.601 |
95% CI (65.4–76.7) |
[22] |
| Sensitivity of diagnosing influenza if present by clinical judgement |
Clin_sens |
uniform |
0.713 |
95% CI (0.65–76.7) |
[22] |
| Costs of NI (oseltamivir) per day |
cAntivir_day |
triangular |
€12.37 |
±20% (€9.89–€14.83) |
Adapted from Rote Liste [Red List] 2019 |
| Costs of Sofia®
|
cSofia |
triangular |
€12 |
±20% (€9.6–€14.40) |
As declared by manufacturer |
| Combined sensitivity of the Sofia® test |
Sofia_sens |
uniform |
0.753 |
95% CI (0.592-0.915) |
[8] |
| Secondary cases due to one unknown influenza case |
sec_flu |
normal |
0.202 |
95% CI (0.154–0.256) |
[23] |
| Costs of productivity loss per day |
cPL_day |
triangular |
€156.99 |
±20% (€125.59–€188.39) |
calculated from Federal Statistical Office data [24] |
| Number of days of HCW out of work due to influenza |
sick_days |
normal |
7.2 days |
SD 8.9 days (5.76–8.64) |
[25,26] |
| Probability of vaccinated HCW |
pVacc_HCW |
normal |
0.401 |
±20% (0.33–0.49) |
[27] |
| Probability that hospitalization is required |
pHosp |
uniform |
0.219 |
0.157-0.23 |
Adapted from [1] |
| Costs of PCR in external laboratory |
cPCR |
triangular |
€44.88 |
€30-€65 |
Nationwide laboratory inquiry |
| Effectiveness of influenza vaccination |
Vacc_eff |
uniform |
0.15 |
0.15–0.49 |
[1,27] |
| Probability of administering NI |
pNI |
uniform |
1 or 0 |
0-1 |
Model assumption |