Overall
16-18-year old
(N=1186)
16-to-18-year-old
Number of Vaso-occlusive Crises
0
(n=716)
1
(n=137)
2+
(n=333)
Patients with SCD, n (%) 60.4 11.6 28.1
Age, mean (SD) 17.0 (0.8) 17.1 (0.8)  16.9 (0.8) 17.0 (0.8)
Gender, n (%)
Male 423 (35.7) 199 (27.8) 65.0 (47.4) 159 (47.7)
Female 763 (64.3) 517 (72.2) 72 (52.6) 174 (52.3)
Ethnicity, n (%) 
White 32 (2.7) 26 (3.6) 2 (1.5) 4 (1.2)
Black 901 (76.0) 587 (82.0) 101 (73.7) 213 (64.0)
Hispanic 14 (1.2) 12 (1.7) 0 (0) 2 (0.6)
Other 233 (19.6) 85 (11.9) 34 (24.8) 114 (34.2)
Missing/Unknown 6 (0.5) 6 (0.8) 0 (0) 0 (0)
Charlson Comorbidity Index, mean (SD) 1.3 (0.7), n=369 1.3 (0.8), n=187 1.3 (0.5), n=41 1.4 (0.8), n=141
VOC Episode, mean (SD) 3.9 (4.2), n=470 0 (0), n=0 1.0 (0), n=137 5.1 (4.4), n=333
SCD Complications, n (%)
Acute 206 (17.4) 70 (9.8) 22 (16.1) 114 (34.2)
Chronic 725 (61.1) 379 (52.9) 80 (58.4) 266 (79.9)
Cerebrovascular Disease 69 (5.8) 45 (6.3) 5 (3.6) 19 (5.7)
Hepatic Disease 76 (6.4) 21 (2.9) 11 (8.0) 44 (13.2)
Pulmonary Disease 369 (31.1) 169 (23.6) 37 (27.0) 163 (48.9)
Renal Disease 106 (8.9) 55 (7.7) 10 (7.3) 41 (12.3)
Spleen Disease 6 (0.5) 0 (0) 0 (0) 6 (1.8)
Other 576 (48.6) 275 (38.4) 60 (43.8) 241 (72.4)
SCD-related HCRU, mean (SD)
Length of Stay (Hospital) 9.0 (14.4), n=544 4.2 (8.1), n=248 5.4 (10.1), n=41 14.3 (17.6), n=255
Hospital Admissions 2.0 (2.3), n=544 1.1 (0.4), n=248 1.3 (0.8), n=41 3.0 (3.0), n=255
ER Visits 3.4 (4.0), n=687 1.8 (1.1), n=283 1.9 (1.3), n=94 5.3 (5.3), n=310
Office Visits 5.0 (4.2), n=806 4.1 (4.0), n=357 4.7 (3.4), n=130 6.1 (4.4), n=319
Other Outpatients Visits 7.9 (11.0), n=831 5.6 (9.9), n=384 6.7 (7.7), n=128 11.1 (12.5), n=319
SCD Managements, mean (SD)
Blood transfusions 8.4 (7.0), n=137 9.0 (7.3), n=50 8.1 (4.9), n=15 8.0 (7.1), n=72
Pneumococcal vaccines 1.1 (0.3), n=100 1.1 (0.3), n=30 1.1 (0.3), n=25 1.2 (0.4), n=45
Meningococcal vaccines 1.2 (0.5), n=227 1.2 (0.5), n=112 1.2 (0.5), n=30 1.2 (0.5), n=85
Bone marrow transplants 1.0 (0.0), n=2 1.0 (0.0), n=2 0.0 (0.0), n=0 0.0 (0.0), n=0
Transcranial doppler ultrasonography 1.2 (0.5), n=105 1.3 (0.7), n=28 1.1 (0.3), n=22 1.2 (0.5), n=55
SCD Medications, mean (SD) 
Antibiotics 2.7 (2.6), n=691 2.4 (2.2), n=387 2.9 (2.7), n=69 3.2 (3.0), n=235
Antidepressants 3.9 (4.1), n=137 3.0 (2.9), n=76 5.6 (3.5), n=10 4.9 (5.2), n=51
Antimetabolite 5.3 (3.2), n=272 5.9 (3.5), n=48 5.8 (3.2), n=51 5.0 (3.1), n=173
Iron chelating therapy 8.6 (10.0), n=70 10.2 (12.3), n=29 4.3 (2.7), n=9 8.3 (8.7), n=32
NSAIDs 2.9 (2.5), n=742 2.1 (1.9), n=370 2.7 (2.1), n=100 4.1 (2.9), n=272
Opioids 4.7 (5.9), n=672 2.0 (2.6), n=263 3.5 (3.2), n=101 7.4 (7.3), m=308
Others 4.3 (3.2), n=353 4.4 (3.4), n=86 4.7 (3.3), n=69 4.1 (3.0), n=198